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Formal Total Synthesis of Manzacidin B via Sequential Diastereodivergent Henry Reaction.

Yuya ArakiNatsumi MiyoshiKazuki MorimotoTakayuki KudohHaruki MizoguchiAkira Sakakura
Published in: The Journal of organic chemistry (2019)
A formal total synthesis of manzacidin B is described. β,β-Disubstituted γ-hydroxy-β-aminoalcohol, the key structure of manzacidin B, is stereoselectively constructed via sequential Henry reactions. By taking advantage of noncovalent interactions, such as intramolecular hydrogen bonding and chelation, we could diastereodivergently control the stereoselectivity of the Henry reaction.
Keyphrases
  • wastewater treatment
  • electron transfer