Somatic genetic alterations in synchronous and metachronous low-grade serous tumours and high-grade carcinomas of the adnexa.

Rajmohan MuraliPier SelenicaDavid N BrownR Keira CheethamRaghu ChandramohanNidia L ClarosNancy BouvierDonavan T ChengRobert A SoslowBritta WeigeltW Glenn McCluggage

Published in: Histopathology (2019)

Our results suggest that progression from SBT to HGSC may take place in a subset of cases, and that at least some of the rare HGSCs lacking TP53 mutations may be derived from a low-grade serous precursor.

Keyphrases

high grade
low grade
copy number
genome wide
gene expression
dna methylation