Gene expression and ultra-structural evidence for metabolic derangement in the primary mitral regurgitation heart.
Mariame Selma KaneJuan Xavier Masjoan JuncosShajer ManzoorMaximiliano GrenettJoo-Yeun OhBetty PatMustafa I AhmedClifton LewisJames E DaviesThomas S DenneyJonathan E McConathyLouis J Dell'ItaliaPublished in: European heart journal open (2024)
The PMR heart has a global ultra-structural and metabolic gene expression pattern of decreased glucose uptake along with increased glycogen and LDs. Further studies must determine whether this presentation is an adaptation or maladaptation in the PMR heart in the clinical evaluation of PMR.