METTL3 promotes chemoresistance in small cell lung cancer by inducing mitophagy.

Yueqin SunWeitao ShenShulu HuQiong LyuQiongyao WangTing WeiWeiliang ZhuJian Zhang

Published in: Journal of experimental & clinical cancer research : CR (2023)

The m6A methyltransferase METTL3 regulates Pink1-Parkin pathway-mediated mitophagy and mitochondrial damage in SCLC cells by targeting DCP2, thereby promoting chemotherapy resistance in patients with SCLC.

Keyphrases

small cell lung cancer
oxidative stress
nlrp inflammasome
locally advanced
brain metastases
chemotherapy induced