Parabiosis Discriminates the Circulating, Endothelial, and Parenchymal Contributions of Endogenous Tissue-Type Plasminogen Activator to Stroke.
Jonathane FuronFlorent LebrunMervé YetimDamien LevardPauline MarieCyrille OrsetSara Martinez de LizarrondoDenis VivienCarine AliPublished in: Stroke (2024)
Together, our data reveal that during thromboembolic stroke, endogenous circulating tPA from endothelial cells sustains a spontaneous recanalization and reperfusion of the tissue, thus, limiting the extension of ischemic lesions. In this context, the impact of endogenous parenchymal tPA is limited.
Keyphrases
- endothelial cells
- atrial fibrillation
- cerebral ischemia
- subarachnoid hemorrhage
- acute myocardial infarction
- genome wide
- brain injury
- blood brain barrier
- electronic health record
- heart failure
- single cell
- high glucose
- middle cerebral artery
- ischemia reperfusion injury
- big data
- percutaneous coronary intervention
- gene expression
- left ventricular
- acute coronary syndrome