Characterization of white matter hyperintensities in Down syndrome.
Alejandra O Morcillo-NietoSara E ZsadanyiJose E Arriola-InfanteMaria Carmona-IraguiVictor MontalJordi PeguerolesMateus Rozalem AranhaLídia Vaqué-AlcázarConcepción PadillaBessy BenejamLaura VidelaIsabel BarroetaSusana FernandezMiren AltunaSandra GiménezSofía González-OrtizNúria BargallóLaia RibasJavier ArranzSoraya TorresMaria Florencia IulitaOlivia BelbinValle CamachoDaniel AlcoleaAlberto LleóJuan ForteaAlexandre BejaninPublished in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2024)
White matter hyperintensities (WMHs) increased 10 years before Alzheimer's disease symptom onset in Down syndrome (DS). WMHs were strongly associated in DS with the neurofilament light chain biomarker. WMHs were more associated in DS with gray matter volume in parieto-temporal areas.