Application of a split-Cre system for high-capacity adenoviral vector amplification.

Manuela Gonzalez-AparicioMaria BunualesIñaki Ortiz de LandazuriJesus PrietoRuben Hernandez-Alcoceba

Published in: Biotechnology journal (2022)

The split-Cre system improves the performance of packaging cells and can reduce the time and cost of HC-AdV amplification up to 30 and 15%, respectively. This may contribute to the standardization of HC-AdV production. This article is protected by copyright. All rights reserved.

Keyphrases

nucleic acid
induced apoptosis
cell cycle arrest
signaling pathway