Essential role of p21 Waf1/Cip1 in the modulation of post-traumatic hippocampal Neural Stem Cells response.

Francesco ChianiValentina MastrorilliNicole MarchettiAndrea MacioceChiara NappiGeorgios StrimpakosMiriam PasquiniAlessia GambadoroJonathan Isacco BattistiniDebora CutuliLaura PetrosiniSara MarinelliRaffaella ScardigliStefano Farioli Vecchioli

Published in: Stem cell research & therapy (2024)

These data demonstrate for the first time a fundamental role of p21 in modulating the post-traumatic hippocampal neurogenic response, by the regulation of the proliferative and differentiative steps of aNSCs/progenitor populations after brain damage.

Keyphrases

neural stem cells
cerebral ischemia
spinal cord injury
oxidative stress
electronic health record
signaling pathway
white matter
resting state
big data
brain injury
blood brain barrier
functional connectivity
deep learning
genetic diversity