Circadian time-dependent effects of experimental colitis on theophylline disposition and toxicity.
Yi YangPengcheng WuJuntao GuoZhixi PanShubin LinWanying ZengCunchuan WangZhiyong DongShuai Wang
Published in: British journal of pharmacology (2024)
Our findings establish a strong link between colitis and chronopharmacology, shedding light on how IBD affects drug disposition and toxicity over time. This research provides a theoretical foundation for optimizing drug dosage in patients with IBD.