Ikoamide, an Antimalarial Lipopeptide from an Okeania sp. Marine Cyanobacterium.
Keitaro IwasakiArihiro IwasakiShimpei SumimotoTeruhiko MatsubaraToshinori SatoTomoyoshi NozakiYumiko Saito-NakanoKiyotake SuenagaPublished in: Journal of natural products (2020)
An antimalarial lipopeptide, ikoamide, was isolated from an Okeania sp. marine cyanobacterium. Its gross structure was established by spectroscopic analyses, and the absolute configuration was clarified based on a combination of chiral-phase HPLC analyses, spectroscopic analyses, and derivatization reactions. Ikoamide showed strong antimalarial activity with an IC50 value of 0.14 μM without cytotoxicity against human cancer cell lines at 10 μM.
Keyphrases
- ms ms
- molecular docking
- plasmodium falciparum
- simultaneous determination
- endothelial cells
- high performance liquid chromatography
- papillary thyroid
- solid phase extraction
- gas chromatography mass spectrometry
- ionic liquid
- squamous cell carcinoma
- young adults
- children with cerebral palsy
- high resolution
- molecular dynamics simulations