Circulating CD8 + mucosal-associated invariant T cells correlate with improved treatment responses and overall survival in anti-PD-1-treated melanoma patients.
Victoria M VorwaldDana M DavisRobert J Van GulickRobert J TorphyJessica S W BorgersJared KlarquistKasey L CoutsCarol M AmatoDasha T CogswellMayumi FujitaMoriah J CastlemanTimothy DavisCatherine LozuponeTheresa M MedinaWilliam A RobinsonLaurent GapinMartin D McCarterRichard P TobinPublished in: Clinical & translational immunology (2022)
Our results suggest that MAIT cells may be a potential predictive marker of responses to immunotherapies and provide rationale for testing MAIT cell-directed therapies in combination with current and next-generation ICIs.