Glioblastoma-Derived Small Extracellular Vesicles: Nanoparticles for Glioma Treatment.
Salome Araujo-AbadAntonio Manresa-ManresaEnrique Rodríguez-CañasMaría Fuentes-BailePilar García-MoralesRicardo MallaviaMiguel SacedaCamino de Juan RomeroPublished in: International journal of molecular sciences (2023)
Glioblastoma (GBM), characterized by fast growth and invasion into adjacent tissue, is the most aggressive cancer of brain origin. Current protocols, which include cytotoxic chemotherapeutic agents, effectively treat localized disease; however, these aggressive therapies present side effects due to the high doses administered. Therefore, more efficient ways of drug delivery have been studied to reduce the therapeutic exposure of the patients. We have isolated and fully characterized small extracellular vesicles (EVs) from seven patient-derived GBM cell lines. After loading them with two different drugs, Temozolomide (TMZ) and EPZ015666, we observed a reduction in the total amount of drugs needed to trigger an effect on tumor cells. Moreover, we observed that GBM-derived small EVs, although with lower target specificity, can induce an effect on pancreatic cancer cell death. These results suggest that GBM-derived small EVs represent a promising drug delivery tool for further preclinical studies and potentially for the clinical development of GBM treatments.
Keyphrases
- drug delivery
- cell death
- end stage renal disease
- newly diagnosed
- chronic kidney disease
- ejection fraction
- peritoneal dialysis
- prognostic factors
- cell proliferation
- papillary thyroid
- white matter
- cell therapy
- cell migration
- lymph node metastasis
- patient reported outcomes
- cerebral ischemia
- subarachnoid hemorrhage
- cell cycle arrest
- young adults
- childhood cancer