Genetic Predictors of Severe Skin Toxicity in Patients with Stage III Colon Cancer Treated with Cetuximab: NCCTG N0147 (Alliance).
Julia D LabadieXinwei HuaTabitha A HarrisonBarbara L BanburyJeroen R HuygheWei SunQian ShiGreg YothersSteven R AlbertsFrank A SinicropeRichard M GoldbergThomas J GeorgeKathryn L PenneyAmanda I PhippsStacey A CohenUlrike PetersAndrew T ChanPolly A NewcombPublished in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology (2020)
Retinoids have shown promise in the treatment of cetuximab-induced skin toxicity, so follow-up work could evaluate whether individuals with the RARA variant would benefit from retinoid therapy.
Keyphrases
- soft tissue
- oxidative stress
- metastatic colorectal cancer
- wound healing
- locally advanced
- diabetic rats
- high glucose
- drug induced
- wild type
- early onset
- genome wide
- big data
- gene expression
- replacement therapy
- radiation therapy
- machine learning
- combination therapy
- dna methylation
- oxide nanoparticles
- rectal cancer
- endothelial cells
- artificial intelligence
- stress induced