Distinct lipidomic signatures in persons living with HIV: combined analysis of ACTG 5260s and MACS/WIHS.

Jennifer JaoLauren C BalmertShan SunGrace A McComseyTodd T BrownPhyllis C TienJudith S CurrierJames H SteinYunping QiuDerek LeRoithIrwin J Kurland

Published in: The Journal of clinical endocrinology and metabolism (2021)

Alterations in the metabolome/lipidome suggest increased lipogenesis for ART-naïve PLHIV vs. HIV-seronegative individuals, increased TAG turnover for RAL vs. ATV/r or DRV/r, and increased inflammation associated with this altered metabolome/lipidome after initiating ART. Future studies are needed to understand cardiometabolic consequences of lipogenesis and inflammation in PLHIV.

Keyphrases

antiretroviral therapy
hiv infected
oxidative stress
hiv positive
human immunodeficiency virus
hiv aids
hiv testing
men who have sex with men
type diabetes
bone mineral density
adipose tissue
current status
metabolic syndrome
dna methylation
postmenopausal women
south africa