Pre-clinical left ventricular myocardial remodeling in patients with Friedreich's ataxia: A cardiac MRI study.
Karen A G TakazakiThiago QuinagliaThiago D VenancioAlberto R M MartinezRavi V ShahTomas G NeilanMichael Jerosch-HeroldOtávio Rizzi Coelho-FilhoMarcondes C FrançaPublished in: PloS one (2021)
LV hypertrophy and concentric LV remodeling in FRDA are associated at the tissue level with an expansion of the ECV and an increase in cardiomyocyte size. The adverse tissue remodeling assessed by ECV and τic is associated with more severe cardiomyopathy classification, suggesting a role for these markers in tracking disease progression.
Keyphrases
- left ventricular
- heart failure
- early onset
- magnetic resonance imaging
- hypertrophic cardiomyopathy
- cardiac resynchronization therapy
- machine learning
- acute myocardial infarction
- mitral valve
- aortic stenosis
- computed tomography
- magnetic resonance
- acute coronary syndrome
- atrial fibrillation
- coronary artery disease
- aortic valve