Humoral and T-cell immune response after three doses of mRNA SARS-CoV-2 vaccines in fragile patients: the Italian VAX4FRAIL study.
Paolo CorradiniChiara AgratiGiovanni ApoloneAlberto MantovaniDiana GiannarelliVincenzo MarascoVeronica BordoniAlessandra SacchiGiulia MatusaliCarlo SalvaraniPier Luigi ZinzaniRenato MantegazzaFabrizio TagliaviniMaria Teresa Lupo-StanghelliniFabio CiceriSilvia DamianAntonio UccelliDaniela FenoglioNicola SilvestrisFausto BaldantiGiulia PiaggioGennaro CilibertoAldo MorroneFranco LocatelliValentina SinnoMaria RescignoMassimo Costantininull nullPublished in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2022)
Immunosuppressive treatment more than disease type per se is a risk factor for a low humoral response after vaccination. The booster dose can improve both humoral and T-cell responses.