Pregnancy in lymphangioleiomyomatosis: clinical and lung function outcomes in two national cohorts.
Angelo M Taveira-DaSilvaSimon R JohnsonPatricia Julien-WilliamsJan JohnsonMario StylianouJoel MossPublished in: Thorax (2020)
Pregnancy in women with lymphangioleiomyomatosis (LAM) has been associated with increased complications and worsening lung function although objective data to advise patients are not available. We assessed lung function and CT scans before and after pregnancy in 16 women with LAM. During the pregnancy, pneumothorax was frequent and mean forced expiratory volume in 1 s (FEV1) fell from 77%±19% prepregnancy to 64%±25% predicted and DLCO from 66±26 to 57±26 (both p<0.01). After pregnancy, rates of FEV1 decline were high and 10 patients required sirolimus. Women with LAM, especially with moderate or advanced disease should be counselled regarding adverse events and loss of lung function during the pregnancy.
Keyphrases
- lung function
- chronic obstructive pulmonary disease
- cystic fibrosis
- air pollution
- preterm birth
- end stage renal disease
- pregnancy outcomes
- ejection fraction
- chronic kidney disease
- newly diagnosed
- peritoneal dialysis
- computed tomography
- body mass index
- type diabetes
- pregnant women
- high intensity
- weight gain
- metabolic syndrome
- intensive care unit
- deep learning
- adipose tissue
- artificial intelligence
- electronic health record
- dual energy
- positron emission tomography