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Synthesis of Pseudooligosaccharides Related to the Capsular Phosphoglycan of Haemophilus influenzae Type a .

Anastasia A KamnevaDmitry V YashunskyElena A KhatuntsevaNikolay E Nifantiev
Published in: Molecules (Basel, Switzerland) (2023)
Synthesis of spacer-armed pseudodi-, pseudotetra-, and pseudohexasaccharides related to the capsular phosphoglycan of Haemophilus influenzae type a , the second most virulent serotype of H. influenzae (after type b ), was performed for the first time via iterative chain elongation using H-phosphonate chemistry for the formation of inter-unit phosphodiester bridges. These compounds were prepared for the design of neoglycoconjugates, as exemplified by the transformation of the obtained pseudohexasaccharide derivative into a biotinylated glycoconjugate suitable for use in immunological studies, particularly in diagnostic screening systems as a coating antigen for streptavidin-coated plates and chip slides.
Keyphrases
  • dengue virus
  • high throughput
  • escherichia coli
  • magnetic resonance
  • image quality
  • zika virus
  • case control