Efficacy assessment of a novel endolysin PlyAZ3aT for the treatment of ceftriaxone-resistant pneumococcal meningitis in an infant rat model.
Luca G ValenteNgoc Dung LeMelissa PittonGabriele ChiffiDenis GrandgirardStephan M JakobDavid R CameronGrégory ReschYok-Ai QueStephen L LeibPublished in: PloS one (2022)
In experimental pneumococcal meningitis, PlyAZ3aT failed to cure the infection due to an inability to reach the CSF. Optimization of the galenic formulation e.g. using liposomes might enable crossing of the BBB and improve treatment efficacy.