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The Effects of Common Genetic Variation in 96 Genes Involved in Thyroid Hormone Regulation on TSH and FT4 Concentrations.

Rosalie B T M SterenborgTessel E GaleslootAlexander TeumerRomana T Netea-MaierDoug SpeedMarcel E MeimaW Edward VisserJohannes W A SmitRobin P PeetersMarco Medici
Published in: The Journal of clinical endocrinology and metabolism (2022)
Here we report the largest candidate gene analysis on thyroid function, resulting in a substantial increase in the number of genetic variants determining TSH and FT4 concentrations. Interestingly, these candidate gene SNPs explain only a minor part of the variation in TSH and FT4 concentrations, which substantiates the need for large genetic studies including common and rare variants to unravel novel, yet unknown, pathways in TH regulation.
Keyphrases
  • copy number
  • genome wide
  • dna methylation
  • genome wide identification
  • gene expression
  • transcription factor