Nuclear respiratory factor 1 transcriptomic signatures as prognostic indicators of recurring aggressive mesenchymal glioblastoma and resistance to therapy in White American females.
Kaumudi BhaweJayanta K DasChangwon YooQuentin FeltyZhenghua GongAlok DeorajJuan P LiuzziNasreen Z EhteshamSeyed E HasnainVarindera Paul SinghIshani MohapatraRicardo Jorge KomotarDeodutta RoyPublished in: Journal of cancer research and clinical oncology (2022)
In summary, our novel discovery shows that NRF1-driven causal genes and miRNAs involved in cancer cell stemness and mesenchymal features contribute to cancer aggressiveness and recurrence of aggressive therapy-resistant glioblastoma.