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Quillaja saponin mitigates methotrexate-provoked renal injury; insight into Nrf-2/Keap-1 pathway modulation with suppression of oxidative stress and inflammation.

Mustafa Ahmed Abdel-ReheimMerhan E AliAhmed Gaafar A GaafarAhmed Amine Ashour
Published in: Journal of pharmaceutical health care and sciences (2024)
In conclusion, our results suggest the prophylactic and/or therapeutic effects of QBS in treating MTX-induced AKI. Such reno-protection is most-likely mediated via Nrf-2 induction that interferes with oxidant load, inflammatory pathways, and proapoptotic signaling.
Keyphrases
  • oxidative stress
  • diabetic rats
  • dna damage
  • ischemia reperfusion injury
  • induced apoptosis
  • acute kidney injury
  • high glucose
  • high dose
  • drug induced
  • radiation therapy
  • endoplasmic reticulum stress