Quillaja saponin mitigates methotrexate-provoked renal injury; insight into Nrf-2/Keap-1 pathway modulation with suppression of oxidative stress and inflammation.

Mustafa Ahmed Abdel-Reheim Merhan E Ali Ahmed Gaafar A Gaafar Ahmed Amine Ashour

Published in: Journal of pharmaceutical health care and sciences (2024)

In conclusion, our results suggest the prophylactic and/or therapeutic effects of QBS in treating MTX-induced AKI. Such reno-protection is most-likely mediated via Nrf-2 induction that interferes with oxidant load, inflammatory pathways, and proapoptotic signaling.

Keyphrases

oxidative stress
diabetic rats
dna damage
ischemia reperfusion injury
induced apoptosis
acute kidney injury
high glucose
high dose
drug induced
radiation therapy
endoplasmic reticulum stress