Quillaja saponin mitigates methotrexate-provoked renal injury; insight into Nrf-2/Keap-1 pathway modulation with suppression of oxidative stress and inflammation.
Mustafa Ahmed Abdel-ReheimMerhan E AliAhmed Gaafar A GaafarAhmed Amine AshourPublished in: Journal of pharmaceutical health care and sciences (2024)
In conclusion, our results suggest the prophylactic and/or therapeutic effects of QBS in treating MTX-induced AKI. Such reno-protection is most-likely mediated via Nrf-2 induction that interferes with oxidant load, inflammatory pathways, and proapoptotic signaling.