Dexmedetomidine Ameliorates Cardiac Ischemia/Reperfusion Injury by Enhancing Autophagy Through Activation of the AMPK/SIRT3 Pathway.

Published in: Drug design, development and therapy (2023)

Dex suppressed oxidative stress and inflammation by promoting autophagy through activating the AMPK/SIRT3 pathway, thus protecting the heart against the I/R injury.

Keyphrases

oxidative stress
ischemia reperfusion injury
diabetic rats
dna damage
skeletal muscle
induced apoptosis
signaling pathway
cell death
heart failure
protein kinase
cardiac surgery
atrial fibrillation
heat shock
acute kidney injury