Nasal high-flow oxygen versus noninvasive ventilation in acute exacerbation of COPD: protocol for a randomised noninferiority clinical trial.
Athanasia PapalampidouEleni BibakiStylianos BoutlasIoannis PantazopoulosNikolaos AthanasiouMelanie MoylanVasileios VlachakosVasileios GrigoropoulosKonstantinos EleftheriouZoe DaniilKonstantinos GourgoulianisIoannis KalomenidisSpyros ZakynthinosEleni IschakiPublished in: ERJ open research (2020)
Given the increasing number of studies demonstrating the physiological effects of NHF in COPD patients, we hypothesise that NHF respiratory support will be noninferior to NIV in patients with AECOPD and mild-to-moderate acute or acute on chronic hypercapnic respiratory failure.
Keyphrases
- respiratory failure
- extracorporeal membrane oxygenation
- clinical trial
- mechanical ventilation
- chronic obstructive pulmonary disease
- end stage renal disease
- acute respiratory distress syndrome
- ejection fraction
- lung function
- open label
- intensive care unit
- prognostic factors
- cystic fibrosis
- phase ii
- phase iii
- air pollution
- patient reported