Transferrin receptor 1 ablation in satellite cells impedes skeletal muscle regeneration through activation of ferroptosis.

Hongrong DingShujie ChenXiaohan PanXiaoshuang DaiGuihua PanZe LiXudong MaiYe TianSusu ZhangBingdong LiuGuangchao CaoZhicheng YaoXiangping YaoLiang GaoLi YangXiaoyan ChenJia SunHong ChenMulan HanYulong YinGuohuan XuHuijun LiWeidong WuZheng ChenJingchao LinLiping XiangJun HuYan LuXiao ZhuLiwei Xie

Published in: Journal of cachexia, sarcopenia and muscle (2021)

Satellite cell-specific deletion of Tfr1 impairs skeletal muscle regeneration with activation of ferroptosis. This phenomenon is recapitulated in skeletal muscle of aged rodents and human sarcopenia. Our study provides mechanistic information for developing novel therapeutic strategies against muscular ageing and diseases.

Keyphrases

skeletal muscle
insulin resistance
stem cells
cell death
induced apoptosis
cell cycle arrest
endothelial cells
single cell
cell therapy
healthcare
type diabetes
oxidative stress
signaling pathway
bone marrow
mesenchymal stem cells
endoplasmic reticulum stress
atrial fibrillation