Folate metabolism modifies chromosomal damage induced by 1,3-butadiene: results from a match-up study in China and in vitro experiments.

Menglong XiangZhi WangPeng ZouXi LingGuowei ZhangZiyuan ZhouJia CaoLin Ao

Published in: Genes and environment : the official journal of the Japanese Environmental Mutagen Society (2021)

We reported that folate metabolism could modify the association between BD exposure and chromosomal damage, and such effect may be partially mediated by DNA hypomethylation, and 5-MTHF supplementation could rescue it.

Keyphrases

oxidative stress
copy number
circulating tumor
cell free
dna methylation
genome wide