Chordoma recruits and polarizes tumor-associated macrophages via secreting CCL5 to promote malignant progression.

Jiuhui XuQianyu ShiJingbing LouBoyang WangWei WangJianfang NiuLei GuoChenglong ChenYiyang YuYi HuangWei GuoJianqiang LanYu ZhuTingting RenXiaodong Tang

Published in: Journal for immunotherapy of cancer (2023)

Our study implicates that the CCL5-CCR5 axis plays an important role in the malignant progression of chordoma and the regulation of macrophages, and that the CCL5-CCR5 axis is a potential therapeutic target in chordoma.

Keyphrases

liver fibrosis
liver injury
dendritic cells
regulatory t cells
drug induced
risk assessment
human health