Compound Library Screening for Synergistic Drug Combinations: mTOR Inhibitor and Proteasome Inhibitor Effective Against Osteosarcoma Cells.

Kunihiro AsanumaTomoki NakamuraKoichi NakamuraTomohito HagiTakayuki OkamotoKouji KitaYumi MatsuyamaKeisuke YoshidaKunihiro AsanumaAkihiro Sudo

Published in: Anticancer research (2022)

The combination of everolimus and bortezomib demonstrated a synergistic effect against OS both in vitro and in vivo. These results indicate that this combination may be useful as a novel therapeutic strategy for OS.

Keyphrases

induced apoptosis
cell cycle arrest
multiple myeloma
cell proliferation
cancer therapy
endoplasmic reticulum stress
cell death
newly diagnosed
signaling pathway
drug delivery