Molecularly defined subsets of Ewing Sarcoma tumors differ in their responses to IGF1R and WEE1 inhibition.

Upendra K Soni Yuhua Wang Ram Naresh Pandey Ryan D Roberts Joseph G Pressey Rashmi S Hegde

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)

IGF1R signaling mechanisms and replication stress levels can vary among Ewing sarcoma tumors (including in the same patient) influencing the effects of IGF1R and WEE1-treatment. These findings make the case for using biopsy-derived predictive biomarkers at multiple stages of Ewing sarcoma disease-management.

Keyphrases

binding protein
pi k akt
growth hormone
case report
peripheral blood