Associations of Genome-Wide Polygenic Risk Score and Risk Factors With Hypertension in a Japanese Population.

Ryosuke Fuji Asahi Hishida Masahiro Nakatochi Yoshiki Tsuboi Koji Suzuki Takaaki Kondo Hiroaki Ikezaki Megumi Hara Rieko Okada Takashi TamuraIppei ShimoshikiryoSadao SuzukiTeruhide KoyamaKiyonori KurikiNaoyuki TakashimaKokichi ArisawaYukihide MomozawaMichiaki Kubo Kenji TakeuchiKenji Wakainull null

Published in: Circulation. Genomic and precision medicine (2022)

A PRS for blood pressure was significantly associated with hypertension and BP traits in a general Japanese population. Our findings also highlighted the importance of a combination of PRS and risk factors for identifying high-risk subgroups.

Keyphrases

blood pressure
genome wide
risk factors
hypertensive patients
heart rate
dna methylation
type diabetes
blood glucose
gene expression
copy number
insulin resistance
metabolic syndrome