Emerging Concepts in Precision Medicine in Axial Spondyloarthritis.
Hugues Allard-ChamardQuan LiProton RahmanPublished in: Current rheumatology reports (2023)
Polygenic risk score has resulted in encouraging results with potential diagnostic utility as it appears to outperform current diagnostic tools. Its performance and generalizability vary with ethnicity. Mendelian randomization has elucidated multiple causal associations, particularly between inflammatory bowel disease and AxSpA. Single-cell transcriptomics (particularly scRNA-seq and scATAC-seq) has identified numerous cell types, including synovial and blood immunological cells, to understand the contribution of both innate and adaptative immunity in AxSpA. Current molecular tools provide an exciting opportunity to advance precision medicine for AxSpA patients. However, extensive research and implementation strategies are still required before they can have an impact in the clinic.
Keyphrases
- single cell
- rna seq
- high throughput
- primary care
- end stage renal disease
- ejection fraction
- immune response
- chronic kidney disease
- induced apoptosis
- newly diagnosed
- genome wide
- stem cells
- dna methylation
- cell cycle arrest
- cell therapy
- disease activity
- quality improvement
- systemic lupus erythematosus
- cell death
- cell proliferation
- gene expression
- ulcerative colitis