Methylome and transcriptome profiling of giant cell arteritis monocytes reveals novel pathways involved in disease pathogenesis and molecular response to glucocorticoids.
Elkyn Estupiñán-MorenoLourdes Ortiz-FernándezTianlu LiJose Hernández-RodríguezLaura CiudadEduardo Andrés-LeónLaura Carmen Terron-CameroSergio Prieto-GonzálezGeorgina Espígol-FrigoléMaria Cinta CidAna MarquezEsteban BallestarJavier MartínPublished in: Annals of the rheumatic diseases (2022)
Our results revealed profound alterations in the methylation and transcriptomic profiles of monocytes from GCA patients, uncovering novel genes and pathways involved in GCA pathogenesis and in the molecular response to GC treatment.