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[Physiopathology and treatment of pulmonary arterial hypertension].

Frédéric PerrosÉtienne-Marie JutantLaurent SavalePeter DorfmüllerMarc HumbertI David Montani
Published in: Medecine sciences : M/S (2023)
Pulmonary arterial hypertension (PAH) is a rare disease affecting mainly the pre-capillary pulmonary vascular bed. However, some forms of the disease have venous/capillary involvement. It is an obstructive remodelling of the pulmonary arterioles coupled with vascular pruning, increasing right ventricular afterload and leading to right heart failure. PAH has a complex pathogeny that is detailed in this review. Current specific treatments target endothelial dysfunction, and primarily aim at vasodilatation. Promising innovative treatments targeting the pulmonary artery remodelling are under development.
Keyphrases
  • pulmonary arterial hypertension
  • pulmonary artery
  • pulmonary hypertension
  • heart failure
  • coronary artery
  • polycyclic aromatic hydrocarbons
  • atrial fibrillation
  • acute heart failure
  • replacement therapy