Enamel defects of Axenfeld-Rieger syndrome and the role of PITX2 in its pathogenesis.

Enamel formation is disturbed in some patients with ARS. Pitx2 knockdown can influence the proliferation and ameloblast differentiation of inner enamel epithelial cells, and PITX2 may regulate cell proliferation via Wnt/β-catenin signaling pathway.