Adverse effects of Hif1a mutation and maternal diabetes on the offspring heart.
Radka CerychovaRomana BohuslavovaFrantisek PapousekDavid SedmeraPavel AbaffyVladimir BenesFrantisek KolarGabriela PavlínkováPublished in: Cardiovascular diabetology (2018)
Together our findings provide evidence that a global reduction in Hif1a gene dosage increases predisposition of the offspring exposed to maternal diabetes to cardiac dysfunction, and also underscore Hif1a as a critical factor in the fetal programming of adult cardiovascular disease.
Keyphrases
- cardiovascular disease
- type diabetes
- high fat diet
- endothelial cells
- birth weight
- glycemic control
- pregnancy outcomes
- heart failure
- oxidative stress
- copy number
- cardiovascular events
- cardiovascular risk factors
- left ventricular
- atrial fibrillation
- metabolic syndrome
- coronary artery disease
- transcription factor
- gene expression
- skeletal muscle
- young adults