Dietary monosodium glutamate increases visceral hypersensitivity in a mouse model of visceral pain.

Bailey J A BrantYang YuAmal Abu OmarJosue O Jaramillo PolancoCintya D Lopez LopezNestor N Jiménez VargasQuentin TsangAbby McDonellKaede TakamiDavid E ReedAlan E LomaxStephen J Vanner Caroline J Tuck

Published in: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society (2023)

These findings demonstrate that repeated exposure to MSG in mice leads to sensitization of jejunal afferent nerves to acute ex vivo exposure to MSG. This may contribute to visceral hypersensitivity reported in response to MSG in patients with IBS.

Keyphrases

drug induced
insulin resistance
mouse model
liver failure
high fat diet induced
chronic pain
pain management
respiratory failure
neuropathic pain
intensive care unit
metabolic syndrome
adipose tissue
hepatitis b virus
skeletal muscle