Blockade of receptors of advanced glycation end products ameliorates diabetic osteogenesis of adipose-derived stem cells through DNA methylation and Wnt signalling pathway.

Maorui ZhangYong LiPengcheng RaoKui HuangDaowen LuoXiaoxiao CaiJingang Xiao

Published in: Cell proliferation (2018)

Our results demonstrate that AGEs-RAGE signalling inhibits the osteogenic potential of ASCs under osteoinductive conditions by modulating DNA methylation and Wnt signalling. FPS-ZM1 can rescue the negative effects of AGEs and provide a possible treatment for bone tissue regeneration in patients with diabetic osteoporosis.

Keyphrases

dna methylation
wound healing
stem cells
bone mineral density
genome wide
type diabetes
cell proliferation
gene expression
postmenopausal women
mesenchymal stem cells
bone marrow
bone regeneration
signaling pathway
mouse model