Immune Response to SARS-CoV-2 Infections in Children with Secondary Immunodeficiencies.

Karolina Kuczborska Ewelina Krzemińska Piotr Buda Edyta Heropolitanska-Pliszka Barbara Piątosa Janusz Ksiażyk

Published in: Journal of clinical immunology (2022)

Children with secondary immunodeficiencies seroconvert in equal percentages but with a significantly lower titer of anti-S antibodies compared to their immunocompetent peers. The lower number of NK cells in the immunocompetent cohort may result from their participation in antiviral immunity, whereas reduced CD4 + /CD8 + T cell ratios among immunocompromised children may be a protective factor against a severe COVID-19.

Keyphrases

sars cov
young adults
nk cells
immune response
coronavirus disease
physical activity
intensive care unit
early onset
dendritic cells
extracorporeal membrane oxygenation