Cantharidin overcomes IL-2Rα signaling-mediated vorinostat resistance in cutaneous T-cell lymphoma through reactive oxygen species.

Man ZhuWenjun TangXiaoyu TangZeren ZhuYina JiangAmmar SarwarHongmei ZhangDake ChuZixi ZhangYanmin Zhang

Published in: Journal for immunotherapy of cancer (2024)

Our study uncovers a novel molecular mechanism of acquired SAHA resistance and also suggests that using cantharidin is a potential approach to overcome CTCL therapy resistance. Our findings underlie the therapeutic potential of cantharidin in treating CTCL.

Keyphrases

reactive oxygen species
stem cells
risk assessment
mesenchymal stem cells
human health
bone marrow
replacement therapy