Super Enhancer-Associated Circular RNA-CircKrt4 Regulates Hypoxic Pulmonary Artery Endothelial Cell Dysfunction in Mice.

Cui MaXiaoying WangLixin ZhangXiangrui ZhuJune BaiSiyu HeJian MeiJiaqi JiangXiaoyu GuanXiaodong ZhengLihui QuDaling Zhu

Published in: Arteriosclerosis, thrombosis, and vascular biology (2023)

These findings demonstrate that a super enhancer-associated circular RNA-circKrt4 modulates PAEC injury to promote pulmonary hypertension by targeting Pura and Glpk.

Keyphrases

pulmonary artery
pulmonary hypertension
pulmonary arterial hypertension
binding protein
transcription factor
coronary artery
endothelial cells
oxidative stress
high fat diet induced
type diabetes
metabolic syndrome
high glucose
vascular endothelial growth factor