Allosterism in the adenosine A 2A and cannabinoid CB 2 heteromer.

Claudia Llinas Del TorrentIu RaïchAngel GonzalezJaume LilloNil Casajuana-MartinRafael FrancoLeonardo PardoGemma Navarro

Published in: British journal of pharmacology (2024)

R, facilitating the independent opening of intracellular cavities for G protein binding. These novel results shed light on a different type of allosteric mechanism and extend the repertoire of GPCR heteromer signalling.

Keyphrases

small molecule
reactive oxygen species
protein kinase
dna binding
high throughput sequencing
binding protein
transcription factor