Deconvolution of BNP and NT-proBNP Immunoreactivities by Mass Spectrometry in Heart Failure and Sacubitril/Valsartan Treatment.

Hélène NouguéThibault MichelFrançois PicardJohan LassusMalha SadouneSaid LaribiAlain Cohen-SolalDamien LogeartJean-Marie LaunayNicolas Vodovar

Published in: Clinical chemistry (2023)

Glycosylation interfered with NT-proBNPir measurement, explaining the discrepant evolution of these 2 biomarkers in patients receiving sacubitril/valsartan. Both BNPir and NT-proBNPir are surrogates of proBNP1-108 production, NT-proBNPir being more robust in the clinical contexts studied.

Keyphrases

heart failure
mass spectrometry
ejection fraction
left ventricular
atrial fibrillation
capillary electrophoresis
acute heart failure