Fully automated radiosynthesis of [18F]LBT999 on TRACERlab FXFN and AllinOne modules, a PET radiopharmaceutical for imaging the dopamine transporter in human brain.
Christine ValaCéline MothesGabrielle ChicheriPauline MagadurGilles ViotJean-Bernard DeloyeSerge MaiaYann BouvetAnne-Claire DupontNicolas ArlicotDenis GuilloteauPatrick EmondJohnny VercouilliePublished in: EJNMMI radiopharmacy and chemistry (2020)
Both modules allow efficient and reproducible radiosynthesis of [18F]LBT999 with good radiochemical yields and a reasonable synthesis time. The developments made on AIO, such as its ability to meet pharmaceutical criteria and to more easily comply with GMP requirements, make it an optimal approach for the potent industrial production of [18F]LBT999 and future wider use.
Keyphrases
- pet imaging
- network analysis
- high resolution
- positron emission tomography
- heavy metals
- deep learning
- wastewater treatment
- machine learning
- current status
- high throughput
- uric acid
- biofilm formation
- anti inflammatory
- mass spectrometry
- cystic fibrosis
- escherichia coli
- fluorescence imaging
- risk assessment
- staphylococcus aureus
- candida albicans