Targeted metabolomics of CSF in healthy individuals and patients with secondary progressive multiple sclerosis using high-resolution mass spectrometry.
Henrik CarlssonSandy AbujraisStephanie HermanPayam Emami KhoonsariTorbjörn ÅkerfeldtAnders SvenningssonJoachim BurmanKim KultimaPublished in: Metabolomics : Official journal of the Metabolomic Society (2020)
The Absolute IDQ-p400 kit could successfully be used for quantifying targeted metabolites in the CSF. Metabolites quantified using LC-HRMS showed superior reproducibility compared to FIA-HRMS.
Keyphrases
- high resolution mass spectrometry
- multiple sclerosis
- liquid chromatography
- mass spectrometry
- ultra high performance liquid chromatography
- gas chromatography
- ms ms
- cancer therapy
- tandem mass spectrometry
- simultaneous determination
- white matter
- cerebrospinal fluid
- drug delivery
- solid phase extraction
- high resolution