Pregnancy and Neonatal Outcomes in SARS-CoV-2 Infection: A Systematic Review.
Reem S ChamseddineFarah WahbehFrank ChervenakLaurent J SalomonBaderledeen AhmedArash Rafii TabriziPublished in: Journal of pregnancy (2020)
With the emergence of SARS-CoV-2 and its rapid spread, concerns regarding its effects on pregnancy outcomes have been growing. We reviewed 245 pregnancies complicated by maternal SARS-CoV-2 infection across 48 studies listed on PubMed and MedRxiv. The most common clinical presentations were fever (55.9%), cough (36.3%), fatigue (11.4%), and dyspnea (12.7%). Only 4.1% of patients developed respiratory distress. Of all patients, 89.0% delivered via cesarean section (n = 201), with a 33.3% rate of gestational complications, a 35.3% rate of preterm delivery, and a concerning 2.5% rate of stillbirth delivery or neonatal death. Among those tested, 6.45% of newborns were reported positive for SARS-CoV-2 infection. Relative to known viral infections, the prognosis for pregnant women with SARS-CoV-2 is good, even in the absence of specific antiviral treatment. However, neonates and acute patients, especially those with gestational or preexisting comorbidities, must be actively managed to prevent the severe outcomes being increasingly reported in the literature.
Keyphrases
- sars cov
- pregnancy outcomes
- pregnant women
- end stage renal disease
- ejection fraction
- newly diagnosed
- chronic kidney disease
- prognostic factors
- respiratory syndrome coronavirus
- weight gain
- preterm birth
- type diabetes
- low birth weight
- risk factors
- coronavirus disease
- birth weight
- weight loss
- gestational age
- preterm infants
- patient reported outcomes
- liver failure
- hepatitis b virus
- sleep quality