Population Pharmacokinetics and Dosing Simulations of Intravenous Oxycodone for Perioperative Pain Relief in Adult Surgical Patients with Obesity.
Sook Hui ChawYoke-Lin LoLi Ling YeapDidi Erwandi Bin Mohamad HaronIna Ismiarti ShariffuddinPublished in: European journal of drug metabolism and pharmacokinetics (2022)
A population pharmacokinetic model using total body weight as a covariate supports the administration of 0.10 mg/kg of intravenous oxycodone as a starting dose and repeated doses of 0.02 mg/kg at 1.5-h intervals to maintain targeted plasma concentrations for analgesia in the obese adult population.
Keyphrases
- body weight
- weight loss
- metabolic syndrome
- pain management
- type diabetes
- high dose
- chronic pain
- insulin resistance
- patients undergoing
- neuropathic pain
- cardiac surgery
- ultrasound guided
- weight gain
- cancer therapy
- high fat diet induced
- bariatric surgery
- spinal cord
- spinal cord injury
- physical activity
- low dose
- acute kidney injury