Direct oral anticoagulant adsorption: Impact on lupus anticoagulant testing-Review of the literature and evaluation on spiked and patient samples.

Pieter M M De Kesel Katrien M J Devreese

Published in: Journal of thrombosis and haemostasis : JTH (2020)

D-S limits DOAC interference in LAC assays. DOAC concentration measurement should be performed in D-S treated samples because incomplete removal may occur. Applying D-S to vitamin K antagonist-containing, heparin-containing, or not-anticoagulated samples may lead to erroneous LAC results. Therefore, D-S should only be used in plasma from DOAC-treated patients.

Keyphrases

direct oral anticoagulants
venous thromboembolism
newly diagnosed
atrial fibrillation
end stage renal disease
ejection fraction
chronic kidney disease
systemic lupus erythematosus
peritoneal dialysis
high throughput
case report
disease activity
rheumatoid arthritis
patient reported outcomes