Development and evaluation of antibody-capture immunoassays for detection of Lassa virus nucleoprotein-specific immunoglobulin M and G.
Martin GabrielDonatus I AdomehJacqueline EhimuanJennifer OyakhilomeEmmanuel O OmomohYemisi IghodaloThomas OlokorKofi BonneyMeike PahlmannPetra EmmerichMichaela LelkeLinda BrunotteStephan ÖlschlägerCorinna Thomé-BolduanBeate Becker-ZiajaCarola BuschIkponmwosa OdiaEphraim Ogbaini-EmovonPeter O OkokhereSylvanus A OkogbeninGeorge O AkpedeHerbert SchmitzDanny A AsogunStephan GuntherPublished in: PLoS neglected tropical diseases (2018)
The ELISAs are not equivalent to RT-PCR for early diagnosis of Lassa fever; however, they are of value in diagnosing patients at later stage. The IgG ELISA may be useful for epidemiological studies and clinical trials due its high specificity, and the higher throughput rate and easier operation compared to IFA.