A Comparison Study of Algorithms to Detect Drug-Adverse Event Associations: Frequentist, Bayesian, and Machine-Learning Approaches.

Minh PhamFeng ChengKandethody Ramachandran

Published in: Drug safety (2020)

Our results will be useful to help choose a method for a given desired level of specificity. Methods popular in the genome-wide association study literature did not perform well because of the sparsity of data and will need modification before their properties can be used in the drug-adverse event association problem.

Keyphrases

machine learning
genome wide association study
adverse drug
big data
systematic review
artificial intelligence
deep learning
drug induced
emergency department
structural basis