Combined small molecule and loss-of-function screen uncovers estrogen receptor alpha and CAD as host factors for HDV infection and antiviral targets.
Eloi R VerrierAmélie WeissCharlotte BachLaura HeydmannVincent Turon-LagotArnaud KoppHoussein El SaghireEmilie CrouchetPatrick PessauxThomas GarciaPatrick PaleMirjam B ZeiselCamille SureauCatherine SchusterLaurent BrinoThomas F BaumertPublished in: Gut (2019)
The discovery of HDV host-dependency factors elucidates the pathogenesis of viral disease biology and opens therapeutic strategies for HDV cure.